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The effect of gelatin incorporation into electrospun poly(l-lactide-co-ɛ-caprolactone) fibers on mechanical properties and cytocompatibility

Paper ID Volume ID Publish Year Pages File Format Full-Text
9583 637 2008 8 PDF Available
Title
The effect of gelatin incorporation into electrospun poly(l-lactide-co-ɛ-caprolactone) fibers on mechanical properties and cytocompatibility
Abstract

Very elastic poly(l-lactide-co-ɛ-caprolactone) (PLCL) (50:50) copolymer blended with gelatin was electrospun into microfibers from a hexafluoroisopropanol solution. PLCL fiber sheet exhibited the unique soft and flexible behavior while gelatin fiber was hard and brittle. As the gelatin content of PLCL/gelatin fibers increased, Young's modulus was increased, but the elongation was decreased compared to those of PLCL. However, fibers containing 10–30 wt% gelatin demonstrated an enhanced tensile strength with still high elongation to be beneficial for tissue engineering scaffolds. The cytocompatibility of electrospun fiber sheets was evaluated by fibroblasts (NIH-3T3) cell culture. The initial cell adhesion on various fibers after 5 h was somewhat similar, but in the order of PLCL > PLCL70/gelatin30 ≈ PLCL50/gelatin50 > PLCL90/gelatin10 ≈ gelatin > PLCL30/gelatin70. However, the cell proliferation exhibited a completely different and strong dependence on the fiber composition: a very high proliferation rate on PLCL90/gelatin10, followed by PLCL > gelatin > PLCL70/gelatin30. Such an enhanced effect of gelatin, especially at 10 wt% content, on strength and cytocompatibility of PLCL/gelatin fibers would be very preferable for tissue engineering scaffolds.

Keywords
PLCL-gelatin fibers; Cytocompatibility; Electrospinning; Fibroblasts
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The effect of gelatin incorporation into electrospun poly(l-lactide-co-ɛ-caprolactone) fibers on mechanical properties and cytocompatibility
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 12, April 2008, Pages 1872–1879
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us