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The effect of local simvastatin delivery strategies on mandibular bone formation in vivo

Paper ID Volume ID Publish Year Pages File Format Full-Text
9590 637 2008 10 PDF Available
Title
The effect of local simvastatin delivery strategies on mandibular bone formation in vivo
Abstract

Systemic simvastatin is known to reduce cholesterol and stimulate modest bone formation, but local surgical placement in polylactic acid domes causes robust bone formation and local swelling. A less invasive and more flexible injection protocol was studied to evaluate the bone-inducing effects compared to surgical implantation. Bone formation rate, short- and long-term bone augmentation histology, and mechanical properties were evaluated to characterize the new bone in a rat bilateral mandible model (test and control sides in same animal). Results demonstrated that multiple (3) injections of 0.5 mg simvastatin effectively reduced soft tissue swelling while preserving bone growth (60% increase of bone width at 24 days) compared to simvastatin dome placement (43% increase at 24 days). Compared to controls, bone formation rate was significantly higher on the simvastatin side, especially in the dome. Three-point bending tests revealed higher maximum force to fracture and stiffness at 24 days with simvastatin injections. Long-term evaluation showed that 55% of maximum new bone formed 24 days post-injection was retained at 90 days.

Keywords
Simvastatin; Local delivery; Bone formation; In vivo; Long-term; Mechanical tests
First Page Preview
The effect of local simvastatin delivery strategies on mandibular bone formation in vivo
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 12, April 2008, Pages 1940–1949
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering