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Investigation of the mechanical properties and porosity relationships in selective laser-sintered polyhedral for functionally graded scaffolds

Paper ID Volume ID Publish Year Pages File Format Full-Text
960 70 2011 8 PDF Available
Title
Investigation of the mechanical properties and porosity relationships in selective laser-sintered polyhedral for functionally graded scaffolds
Abstract

An important requirement for a bone tissue engineering scaffold is a stiffness gradient that mimics that of native bone. Such scaffolds can be achieved by controlling their structure and porosity and are termed functionally graded scaffolds (FGS). Currently, the main challenges in FGS fabrication include the iterative and tedious design process as well as a heavy reliance on the user’s CAD/CAM skills. This work aims to bring automated FGS production a step closer by providing a database that correlates scaffold porosity values and the corresponding compressive stiffness and integrating it into the design process. To achieve this goal, scaffolds with different structural configurations were designed using CASTS (Computer Aided System for Tissue Scaffolds), an in-house developed library system consisting of 13 different polyhedral units that can be assembled into scaffold structures. Polycaprolactone (PCL) was chosen as the scaffold material, while selective laser sintering, a powder-based rapid prototyping or additive manufacturing system was employed to fabricate the scaffolds. Mathematical relations correlating scaffold porosity and compressive stiffness readings were formulated and compiled. In addition, cytotoxicity assessment was conducted to evaluate the toxicity of the fabricated PCL scaffolds. Lastly, a brief demonstration of how the formulated relations are used in the FGS design process is presented.

Keywords
Bone tissue engineering; Functionally graded scaffolds; Rapid prototyping; Mechanical properties; Computer aided tissue engineering
First Page Preview
Investigation of the mechanical properties and porosity relationships in selective laser-sintered polyhedral for functionally graded scaffolds
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 2, February 2011, Pages 530–537
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering