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Magnetic nanoparticles encapsulated into biodegradable microparticles steered with an upgraded magnetic resonance imaging system for tumor chemoembolization

Paper ID Volume ID Publish Year Pages File Format Full-Text
9614 638 2009 6 PDF Available
Title
Magnetic nanoparticles encapsulated into biodegradable microparticles steered with an upgraded magnetic resonance imaging system for tumor chemoembolization
Abstract

In this work, therapeutic magnetic micro carriers (TMMC) guided in real time by a magnetic resonance imaging (MRI) system are proposed as a mean to improve drug delivery to tumor sites. MRI steering constraints and physiological parameters for the chemoembolization of liver tumors were taken into account to design magnetic iron–cobalt nanoparticles encapsulated into biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) microparticles with the appropriate saturation magnetization (Ms). FeCo nanoparticles displayed a diameter of 182 nm and an Ms of 209 emu g−1. They were coated with a multilayered graphite shell to minimize the reduction of Ms during the encapsulation steps. FeCo–PLGA microparticles, with a mean diameter of 58 μm and an Ms of 61 emu g−1, were steered in a phantom mimicking the hepatic artery and its bifurcation, with a flow in the same order of magnitude as that of the hepatic artery flow. The steering efficiency, defined as the amount of FeCo–PLGA microparticles in the targeted bifurcation channel divided by the total amount of FeCo–PLGA microparticles injected, reached 86%. The data presented in this paper confirms the feasibility of the steering of these TMMC.

Keywords
Magnetism; Nanoparticle; Microencapsulation; MRI (magnetic resonance imaging); Embolization
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Magnetic nanoparticles encapsulated into biodegradable microparticles steered with an upgraded magnetic resonance imaging system for tumor chemoembolization
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 31, October 2009, Pages 6327–6332
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us