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Nanostructured polyelectrolyte multilayer drug delivery systems for bone metastasis prevention

Paper ID Volume ID Publish Year Pages File Format Full-Text
9619 638 2009 7 PDF Available
Title
Nanostructured polyelectrolyte multilayer drug delivery systems for bone metastasis prevention
Abstract

Polyelectrolyte multilayers (PEM) are well established nanoarchitectures with numerous potential applications, in particular as biomaterial coatings. They may exhibit specific biological properties in terms of controlled cell activation or local drug delivery. Here, in a new approach for bone metastasis prevention, we employed poly-l-lysine covalently grafted with β-cyclodextrin as a polycationic vector (PLL–CD) for the antitumor bisphosphonate drug risedronate (RIS). Molar ratio for maximum loading of the PLL–CD vector with RIS was determined by Raman microspectroscopy. The efficacy of RIS at inhibiting cancer cell invasion in vitro was strongly enhanced upon complexation, whatever PLL–CD:RIS complexes were in solution or embedded into PEM nanoarchitectures. Complexes in solution also clearly prevented cancer-induced bone metastasis in animals. Incorporation of the complexes into PEM nanoarchitectures covering bone implants appears of interest for in situ prevention of bone metastasis after ablation.

Keywords
Bioactive coatings; Polyelectrolyte multilayers; Bone metastasis; Bisphosphonates; Cyclodextrins
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 31, October 2009, Pages 6367–6373
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us