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The effect of a laminin-5-derived peptide coated onto chitin microfibers on re-epithelialization in early-stage wound healing

Paper ID Volume ID Publish Year Pages File Format Full-Text
9634 639 2010 6 PDF Available
Title
The effect of a laminin-5-derived peptide coated onto chitin microfibers on re-epithelialization in early-stage wound healing
Abstract

Considerable effort has been directed towards regenerating defective tissues using tissue-engineering methods. Recently, peptides have been recognized as a valuable scientific tool in the field of tissue-engineering. The PPFLMLLKGSTR motif of the human laminin-5 α3 chain has been previously reported to promote keratinocyte survival; however, the in vivo effects of the PPFLMLLKGSTR motif have not yet been studied. These studies raised the hypothesis that a laminin-5-derived peptide can promote wound healing by accelerating re-epithelialization in vivo. To examine this hypothesis, we applied chitin microfibrous matrices coated with the PPFLMLLKGSTR motif in both rat and rabbit full-thickness cutaneous wound models. Compared with vehicle-treated and peptide-treated cutaneous wounds, the application significantly promoted early-stage wound healing by accelerating re-epithelialization, notably reduced inflammatory cell infiltration, and prominently enhanced fibroblast proliferation. These findings support our hypothesis that the PPFLMLLKGSTR motif acts as a very effective wound healing accelerator by enhancing re-epithelialization.

Keywords
Laminin-5-derived peptide; Wound dressing material; Tissue-engineering; Re-epithelialization; Wound healing
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The effect of a laminin-5-derived peptide coated onto chitin microfibers on re-epithelialization in early-stage wound healing
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 17, June 2010, Pages 4725–4730
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us