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Assessment of using Laponite® cross-linked poly(ethylene oxide) for controlled cell adhesion and mineralization

Paper ID Volume ID Publish Year Pages File Format Full-Text
964 70 2011 10 PDF Available
Title
Assessment of using Laponite® cross-linked poly(ethylene oxide) for controlled cell adhesion and mineralization
Abstract

The in vitro cytocompatibility of silicate (Laponite® clay) cross-linked poly(ethylene oxide) (PEO) nanocomposite films using MC3T3-E1 mouse preosteoblast cells was investigated while cell adhesion, spreading, proliferation and mineralization were assessed as a function of film composition. By combining the advantageous characteristics of PEO polymer (hydrophilic, prevents protein and cell adhesion) with those of a synthetic and layered silicate (charged, degradable and potentially bioactive) some of the physical and chemical properties of the resulting polymer nanocomposites could be controlled. Hydration, dissolution and mechanical properties were examined and related to cell adhesion. Overall, this feasibility study demonstrates the ability of using model Laponite cross-linked PEO nanocomposites to create bioactive scaffolds.

Keywords
Poly(ethylene oxide); Layered silicate; Laponite clay; Nanocomposite; Cell adhesion
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Assessment of using Laponite® cross-linked poly(ethylene oxide) for controlled cell adhesion and mineralization
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 2, February 2011, Pages 568–577
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us