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Progress in developing cationic vectors for non-viral systemic gene therapy against cancer

Paper ID Volume ID Publish Year Pages File Format Full-Text
9653 640 2008 20 PDF Available
Title
Progress in developing cationic vectors for non-viral systemic gene therapy against cancer
Abstract

Initially, gene therapy was viewed as an approach for treating hereditary diseases, but its potential role in the treatment of acquired diseases such as cancer is now widely recognized. The understanding of the molecular mechanisms involved in cancer and the development of nucleic acid delivery systems are two concepts that have led to this development. Systemic gene delivery systems are needed for therapeutic application to cells inaccessible by percutaneous injection and for multi-located tumor sites, i.e. metastases. Non-viral vectors based on the use of cationic lipids or polymers appear to have promising potential, given the problems of safety encountered with viral vectors. Using these non-viral vectors, the current challenge is to obtain a similarly effective transfection to viral ones. Based on the advantages and disadvantages of existing vectors and on the hurdles encountered with these carriers, the aim of this review is to describe the “perfect vector” for systemic gene therapy against cancer.

Keywords
Carrier; Nucleic acids; Stealthy; Poly(ethylene glycol); Targeting system; Intracellular trafficking
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Progress in developing cationic vectors for non-viral systemic gene therapy against cancer
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issues 24–25, August–September 2008, Pages 3477–3496
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us