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Nanostructured conductive material containing ferrocenyl for reagentless amperometric immunosensors

Paper ID Volume ID Publish Year Pages File Format Full-Text
9687 642 2008 8 PDF Available
Title
Nanostructured conductive material containing ferrocenyl for reagentless amperometric immunosensors
Abstract

This work describes a two-step conjugate synthesis of a porous organometallic nanostructured materials composed of ferrocenemonocarboxylic (Fc–COOH) and 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) and then a reagentless amperometric immunosensor prepared with positively charged gold nanoparticles (PGN) immobilized in this nanostructure conductive film is developed. This nanostructured material containing ferrocenyl (PTC–Fc) could easily form stable film on the electrode surface with efficient redox-activity and excellent conductivity. Furthermore, with the negatively charged surface, this film can be used as an interface to adsorbing the PGN, which was prepared in organic solvents at relatively high concentrations with improved monodispersity compared to those prepared in aqueous solution. The presence of PGN provided a congenial microenvironment for adsorbed biomolecules and decreased the electron-transfer impedance. Thus, with carcinoembryonic antibody (anti-CEA) as a model antibody, the proposed immunosensor showed rapid and highly sensitive amperometric response to carcinoembryonic antigen (CEA) with acceptable preparation reproducibility and stability.

Keywords
PTC–Fc; Positively charged gold nanoparticles (PGN); Amperometric immunosensor; Carcinoembryonic antigen (CEA)
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Nanostructured conductive material containing ferrocenyl for reagentless amperometric immunosensors
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 10, April 2008, Pages 1501–1508
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us