fulltext.study @t Gmail

Intracellular delivery of core–shell fluorescent silica nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
9690 642 2008 7 PDF Available
Title
Intracellular delivery of core–shell fluorescent silica nanoparticles
Abstract

Highly fluorescent core–shell silica nanoparticles made by the modified Stöber process (C dots) are promising as tools for sensing and imaging subcellular agents and structures but will only be useful if they can be easily delivered to the cytoplasm of the subject cells. This work shows that C dots can be electrostatically coated with cationic polymers, changing their surface charge and enabling them to escape from endosomes and enter the cytoplasm and nucleus. As an example of cellular delivery, we demonstrate that these particles can also be complexed with DNA and mediate and trace DNA delivery and gene expression.

Keywords
DNA; Silica; Surface modification; Confocal microscopy; Cell viability; Drug delivery
First Page Preview
Intracellular delivery of core–shell fluorescent silica nanoparticles
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 10, April 2008, Pages 1526–1532
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering