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Injectable hyaluronic acid–tyramine hydrogels for the treatment of rheumatoid arthritis

Paper ID Volume ID Publish Year Pages File Format Full-Text
974 70 2011 9 PDF Available
Title
Injectable hyaluronic acid–tyramine hydrogels for the treatment of rheumatoid arthritis
Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by inflammation of the synovial membrane, leading in turn to articular cartilage destruction. In this work, injectable tyramine modified hyaluronic acid (HA–Tyr) hydrogels were developed for the treatment of RA. HA–Tyr conjugate was synthesized by amide bond formation between carboxyl groups of HA and amine groups of tyramine. Then, HA–Tyr hydrogels were prepared by radical crosslinking reaction using H2O2 and horse-radish peroxidase. Intra-articular injection of HA–Tyr hydrogels encapsulating dexamethasone (DMT) as a model drug resulted in successful treatment of RA with reduced interlukine-6, prostaglandin E2 and four types of cytokine levels in collagen-induced arthritis animal models. Histological analysis with hematoxylin and eosin (H&E) staining also confirmed the therapeutic effect of injectable HA–Tyr hydrogels with DMT. Taken together, the injectable HA–Tyr hydrogels were thought suitable to be developed as a therapeutically effective drug carrier for the treatment of RA.

Keywords
Hyaluronic acid; Hydrogel; Dexamethasone; Drug delivery; Rheumatoid arthritis
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Injectable hyaluronic acid–tyramine hydrogels for the treatment of rheumatoid arthritis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 2, February 2011, Pages 666–674
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us