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Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes

Paper ID Volume ID Publish Year Pages File Format Full-Text
9746 644 2009 7 PDF Available
Title
Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes
Abstract

A targeted drug delivery system that is triggered by changes in pH based on single wall carbon nanotubes (SWCNTs), derivatized with carboxylate groups and coated with a polysaccharide material, can be loaded with the anticancer drug doxorubicin (DOX). The drug binds at physiological pH (pH 7.4) and is only released at a lower pH, for example, lysosomal pH and the pH characteristic of certain tumor environments. By manipulating the surface potentials of the modified nanotubes through modification of the polysaccharide coating, both the loading efficiency and release rate of the associated DOX can be controlled. Folic acid (FA), a targeting agent for many tumors, can be additionally tethered to the SWCNTs to selectively deliver DOX into the lysosomes of HeLa cells with much higher efficiency than free DOX. The DOX released from the modified nanotubes has been shown to damage nuclear DNA and inhibit the cell proliferation.

Keywords
Single wall carbon nanotubes (SWCNTs); Targeted drug delivery; Chitosan; Alginate sodium; Nanomedicine
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Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 30, October 2009, Pages 6041–6047
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us