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Prolonged local antibiotics delivery from hydroxyapatite functionalised with cyclodextrin polymers

Paper ID Volume ID Publish Year Pages File Format Full-Text
9751 644 2009 8 PDF Available
Title
Prolonged local antibiotics delivery from hydroxyapatite functionalised with cyclodextrin polymers
Abstract

Per-operative infection is a common complication for bone-graft surgery. Combining antiseptic agents with graft materials may offer a solution by increasing local drug concentration at target sites. Aiming to achieve a sustained local antibiotic (ATB) delivery for a widely applied bone substitute material - hydroxyapatite (HA), we attempted incorporating hydroxypropyl-β-cyclodextrin polymer (polyHPβCD) into microporous HA via impregnating either in a CD monomers mixture solution or a pre-synthesized CD polymer solution, followed by thermal fixation processing. In such functionalised material (CD-HA), polyHPβCD could entrap ATBs and release them progressively. Infrared-spectroscopic analysis confirmed the presence of polyHPβCD in functionalised HA via both processing pathways; polyHPβCD functionalisation yields were quantitated by thermogravimetric analysis for optimising the processing regime. Ciprofloxacin (CFX) and vancomycin (VCM), commonly applied in orthopaedics, have been respectively loaded on CD-HA by dip-coating. For both ATBs, kinetic release test in phosphate buffered saline showed significantly increased initial-burst amount and prolonged release from CD-HA compared with those from non-functionalised HA. Encouragingly, ATBs loaded CD-HA also revealed a prolonged bacteriostatic activity against Staphylococcus aureus and progressively increased cytocompatibility to osteoblasts (MC3T3-E1). Overall, polyHPβCD functionalisation on HA could be an effective drug-delivery model for loading different drug molecules in prevention of infection.

Keywords
Hydroxyapatite; Antibacterial; Surface modification; Bone graft; Drug delivery
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Prolonged local antibiotics delivery from hydroxyapatite functionalised with cyclodextrin polymers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 30, October 2009, Pages 6086–6093
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us