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Simultaneous in vivo comparison of bone substitutes in a guided bone regeneration model

Paper ID Volume ID Publish Year Pages File Format Full-Text
9762 645 2008 6 PDF Available
Title
Simultaneous in vivo comparison of bone substitutes in a guided bone regeneration model
Abstract

A direct, simultaneous comparison of bone substitutes is hampered by the limited number of samples that can be tested simultaneously. The goal of this study was to establish a preclinical model for guided bone regeneration that offers testing of different bone substitutes in a one-wall defect situation. We show here that up to eight titanium hemispheres can be placed on the calvaria of minipigs. To establish our model, titanium hemispheres were filled with and without Bio-Oss®, a deproteinized bovine bone mineral, Ostim®, an aqueous paste of synthetic nanoparticular hydroxyapatite, and Osteoinductal®, an oily calcium hydroxide suspension, before being positioned on the calvaria. After 6 and 12 weeks, titanium hemispheres were subjected to histological and histomorphometric analysis. We show here that bone filled approximately one-tenth of the area below the hemispheres which were left empty, indicating a critical size model for guided bone regeneration. In accordance with the documented osteoconductive properties of Bio-Oss® and Ostim®, titanium hemispheres were almost completely filled with bone. Moreover, the expected degradation profile of Bio-Oss® and Ostim® could be confirmed by histologic and histomorphometric analysis. Under the same conditions, Osteoinductal® failed to exert osteoconductive properties, rather a progressive resorption of the host bone was observed. These results demonstrate that the preclinical model presented here is suitable to simultaneously compare bone substitutes with different material properties. Our model based on the titanium hemispheres allows evaluation of graft consolidation under standardized conditions thereby avoiding intra-individual variations.

Keywords
In vivo test; Bone graft; Bone ingrowth; Bone regeneration; Osteoconduction; Degradation
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Simultaneous in vivo comparison of bone substitutes in a guided bone regeneration model
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 22, August 2008, Pages 3195–3200
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us