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Neuronal cell growth on iridium oxide

Paper ID Volume ID Publish Year Pages File Format Full-Text
9808 648 2010 13 PDF Available
Title
Neuronal cell growth on iridium oxide
Abstract

Iridium oxide is an attractive material for the development of novel multi electrode array (MEA) systems that provide electrodes for stimulation as well as recording single neurons. In this study the biocompatibility of pure iridium and different iridium oxides that differ characteristically in their surface roughness was investigated using two different biological test systems, insect and vertebrate neurons. Iridium oxide surfaces were coated with Concanavalin A and poly-(d)-lysine. In detailed investigations (Ra value determination, contact angle measurement, marker enzyme assay) the surface characteristics of non-modified and coated iridium oxide films were analysed, demonstrating that the materials can be successfully coated. Furthermore, we show that locust neurons grow well on all substrates tested, while chicken neurons need coated surfaces for proper adhesion. Increasing the roughness of iridium oxide films, which in principle could improve cell adhesion, did not improve the neurocompatibility. These results show that in future applications iridium oxide films can be used with surface morphologies previously shown to be optimal for stimulation purposes (cauliflower-like surface structure).

Keywords
Biocompatibility; Iridium; Surface modification; Cell culture
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 6, February 2010, Pages 1055–1067
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us