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Biodegradable injectable polyurethanes: Synthesis and evaluation for orthopaedic applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
9872 651 2008 9 PDF Available
Title
Biodegradable injectable polyurethanes: Synthesis and evaluation for orthopaedic applications
Abstract

Biodegradable polyurethanes offer advantages in the design of injectable or preformed scaffolds for tissue engineering and other medical implant applications. We have developed two-part injectable prepolymer systems (prepolymer A and B) consisting of lactic acid and glycolic acid based polyester star polyols, pentaerythritol (PE) and ethyl lysine diisocyanate (ELDI). This study reports on the formulation and properties of a series of cross linked polyurethanes specifically developed for orthopaedic applications. Prepolymer A was based on PE and ELDI. Polyester polyols (prepolymer B) were based on PE and dl-lactic acid (PEDLLA) or PE and glycolic acid (PEGA) with molecular weights 456 and 453, respectively. Several cross linked porous and non-porous polyurethanes were prepared by mixing and curing prepolymers A and B and their mechanical and thermal properties, in vitro (PBS/37 °C/pH 7.4) and in vivo (sheep bi-lateral) degradation evaluated. The effect of incorporating β-tricalcium phosphate (β-TCP, 5 microns, 10 wt.%) was also investigated. The cured polymers exhibited high compressive strength (100–190 MPa) and modulus (1600–2300 MPa). β-TCP improved mechanical properties in PEDLLA based polyurethanes and retarded the onset of in vitro and in vivo degradation. Sheep study results demonstrated that the polymers in both injectable and precured forms did not cause any surgical difficulties or any adverse tissue response. Evidence of new bone growth and the gradual degradation of the polymers were observed with increased implant time up to 6 months.

Keywords
Injectable polyurethanes; In vitro degradation; In vivo degradation; Biocompatibility; Mechanical properties; Orthopaedic
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Biodegradable injectable polyurethanes: Synthesis and evaluation for orthopaedic applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 28, October 2008, Pages 3762–3770
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us