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Induced stepwise conformational change of human serum albumin on carbon nanotube surfaces

Paper ID Volume ID Publish Year Pages File Format Full-Text
9881 651 2008 9 PDF Available
Title
Induced stepwise conformational change of human serum albumin on carbon nanotube surfaces
Abstract

Non-covalent adsorption of proteins onto carbon nanotubes is important to understand the environmental and biological activity of carbon nanotubes as well as their potential applications in nanostructure fabrication. In this study, the adsorption dynamics and features of a model protein (the A sub-domain of human serum albumin) onto the surfaces of carbon nanotubes with different diameters were investigated out by molecular dynamics simulation. The adsorption behaviors were observed by both trajectory and quantitative analyses. During the adsorption process, the secondary structures of α-helices in the model protein were slightly affected. However, the random coils connecting these α-helices were strongly affected and this made the tertiary structure of protein change. The conformation and orientation selection of the protein were induced by the properties and the texture of surfaces indicated by the interaction curve. In addition, the stepwise adsorption dynamics of these processes are found. The mechanism of induced stepwise conformational change of protein on carbon nanotube surfaces would be helpful to better understand the protein–surface interaction at the molecular level.

Keywords
Human serum albumin; Carbon nanotube; Protein adsorption; Stepwise conformational change; Protein-surface interaction
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Induced stepwise conformational change of human serum albumin on carbon nanotube surfaces
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 28, October 2008, Pages 3847–3855
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us