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Design and evaluation of polypseudorotaxanes of pegylated insulin with cyclodextrins as sustained release system

Paper ID Volume ID Publish Year Pages File Format Full-Text
9883 651 2008 6 PDF Available
Title
Design and evaluation of polypseudorotaxanes of pegylated insulin with cyclodextrins as sustained release system
Abstract

Supramolecular assemblies have attracted a great attention, due to their intriguing topologies and their application in various fields such as nanodevices, sensors, molecular switches, and drug delivery systems. In this study, we prepared the monosubstituted insulin with poly(ethylene glycol) (PEG, MW about 2200) and its cyclodextrin (CyD) polypseudorotaxanes. The pegylated insulin formed polypseudorotaxanes with α- and γ-CyDs, by inserting one PEG chain in the α-CyD cavity and two PEG chains in the γ-CyD cavity. The pegylated insulin/α- and γ-CyD polypseudorotaxanes were less soluble in water and the release rate of the drug decreased in the order of drug alone > the γ-CyD polypseudorotaxane > the α-CyD polypseudorotaxane. The plasma levels of the pegylated insulin after subcutaneous administration of the γ-CyD polypseudorotaxane to rats were significantly prolonged, accompanying an increase in the area under plasma concentration-time curve, which was clearly reflected in the prolonged hypoglycemic effect. The results indicated that the pegylated insulin/CyD polypseudorotaxanes can work as a sustained drug release system, and the polypseudorotaxane formation with CyDs may be useful as a sustained drug delivery technique for other pegylated proteins and peptides.

Keywords
Cyclodextrin; Pegylated insulin; Polypseudorotaxane; Sustained release; Drug delivery system
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Design and evaluation of polypseudorotaxanes of pegylated insulin with cyclodextrins as sustained release system
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 28, October 2008, Pages 3866–3871
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us