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Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions

Paper ID Volume ID Publish Year Pages File Format Full-Text
9894 652 2007 9 PDF Available
Title
Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions
Abstract

Peritoneal adhesions are serious sequelae of surgery, and can cause significant morbidity and/or mortality due to pain, infertility, and bowel obstruction. We have designed and synthesized novel dextran (DX)-based injectable hydrogels for adhesion prevention, which are formed by mixing hydrazide-modified carboxymethyldextran (CMDX–ADH) with aldehyde-modified DX (DX–CHO) or carboxymethylcellulose (CMC–CHO). At high polymer concentrations, hydrogels formed very quickly upon mixing, e.g. 5% CMDX–ADH with 6% DX–CHO (CMDX–DX; 1.8 s) and 5% CMDX–ADH with 6% CMC–CHO (CMDX–CMC; 5.8 s). CMDX–DX shrank after gelling, while CMDX–CMC swelled. CMDX–ADH and CMC–CHO showed minimal to mild cytotoxicity to mesothelial cells and macrophages in vitro, while DX–CHO was very cytotoxic. However, all cross-linked gels had very mild cytotoxicity. When applied in a rabbit sidewall defect-bowel abrasion model of adhesion formation, CMDX–CMC greatly reduced the formation of adhesions while CMDX–DX worsened them.

Keywords
Post-operative adhesion; Dextran; Carboxymethyl dextran; Carboxymethyl cellulose; In situ cross-linking hydrogel; Rabbit sidewall defect-cecum abrasion modelCMDX: carboxymethyldextran; CMDXn: carboxymethyldextran of molecular weight nkDa; DX: dextran; HA:
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Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 23, August 2007, Pages 3418–3426
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us