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Co-polypeptides of 3,4-dihydroxyphenylalanine and l-lysine to mimic marine adhesive protein

Paper ID Volume ID Publish Year Pages File Format Full-Text
9898 652 2007 13 PDF Available
Title
Co-polypeptides of 3,4-dihydroxyphenylalanine and l-lysine to mimic marine adhesive protein
Abstract

Co-polypeptides containing 3,4-dihydroxyphenylalanine (DOPA) and l-lysine were synthesized to mimic the marine adhesive proteins through ring-opening polymerizations. The effects of composition, molecular weight, and curing agents on the adhesive properties, swelling, and degradation behavior of synthetic polypeptide were investigated. Ferric ion was introduced to the system to optimize both adhesive strength and water resistance, simulating the specificity of metal-mediated cross-linking of the marine mussel adhesives. The polypeptide was used to bond on porcine skin and porcine bone in vitro to evaluate the adhesive properties. Furthermore, outcomes of the cell culture of both co-polypeptide and co-polypeptide-modified ethylene vinyl acetate (EVA) demonstrated good cell affinity, which would provide basic data for the application of the co-polypeptide in the biomaterial field.

Keywords
Biomimetic material; Copolymer; Polyamino acid; Tissue adhesive; Swelling
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 23, August 2007, Pages 3456–3468
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us