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An artificial extracellular matrix created by hepatocyte growth factor fused to IgG-Fc

Paper ID Volume ID Publish Year Pages File Format Full-Text
9901 653 2010 8 PDF Available
Title
An artificial extracellular matrix created by hepatocyte growth factor fused to IgG-Fc
Abstract

The design of artificial extracellular matrices (ECM) has attracted much attention in tissue engineering and regenerative medicine as well as in molecular biology research. A recombinant hepatocyte growth factor (HGF), fused to an immunoglobulin G (IgG) Fc region (abbreviated as AeHGF-Fc) was constructed and confirmed by Western blot assay. Almost similar amounts of HepG2 cells adhered to AeHGF-Fc-coated surface compared to collagen-coated one with large morphological changes. Immobilized AeHGF-Fc continuously activated Akt in HepG2 cells whereas Akt activation induced by soluble HGF rapidly decreased with time, indicating that immobilized AeHGF-Fc follows different signal transduction pathways compared to soluble HGF.

Keywords
Hepatocyte growth factor; ECM (extracellular matrix); Cell morphology; HepG2; c-Met; Akt
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An artificial extracellular matrix created by hepatocyte growth factor fused to IgG-Fc
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 5, February 2010, Pages 802–809
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us