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Hydroxyapatite/biodegradable poly(l-lactide–co-ε-caprolactone) composite microparticles as injectable scaffolds by a Pickering emulsion route

Paper ID Volume ID Publish Year Pages File Format Full-Text
991 70 2011 8 PDF Available
Title
Hydroxyapatite/biodegradable poly(l-lactide–co-ε-caprolactone) composite microparticles as injectable scaffolds by a Pickering emulsion route
Abstract

Hydroxyapatite (HAp)/biodegradable poly(l-lactide–co-ε-caprolactone) (P(LA/CL)) composite microparticles were fabricated as an injectable scaffold via the Pickering emulsion route in the absence of any molecular surfactants. A stable oil in water emulsion was obtained using water dispersed HAp nanocrystals as the particulate emulsifier and a dichloromethane (CH2Cl2) solution of P(LA/CL) as the oil phase. The concentration–viscosity relationship of the P(LA/CL) solution and its influence on the formation of a stable emulsion were investigated. The dependence of homogenization on the concentration of the P(LA/CL) solution and shear speed of homogenization was also evaluated. HAp/P(LA/CL) microparticles of various morphologies, such as plates and spheres, or with various surface morphologies were realized through adjustment of the concentration and composition of the P(LA/CL) solution. The microparticles were observed by optical microscopy and scanning electronic microscopy and their size distributions measured using a microparticle size analyzer. The weight percentages of HAp nanocrystals on the HAp/P(LA/CL) microparticles of different average sizes were measured by thermogravimetric analysis.

Keywords
Pickering emulsion; Poly(l-lactide–co-ε-caprolactone); Composite; Morphology; Scaffold
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Hydroxyapatite/biodegradable poly(l-lactide–co-ε-caprolactone) composite microparticles as injectable scaffolds by a Pickering emulsion route
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 2, February 2011, Pages 821–828
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us