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Cytotoxicity of implantable microelectrode arrays produced by laser micromachining

Paper ID Volume ID Publish Year Pages File Format Full-Text
9912 653 2010 8 PDF Available
Title
Cytotoxicity of implantable microelectrode arrays produced by laser micromachining
Abstract

Implantable high-density microelectrode arrays have been successfully fabricated using laser micromachining of conventional implant materials, polydimethylsiloxane (PDMS) and platinum (Pt) foil. This study investigates the impact of modifying PDMS and Pt with high power laser beams and the possible toxicity of by-products that may remain on the implantable device. Materials were characterised both chemically and biologically through x-ray photoelectron spectroscopy (XPS), cell growth inhibition assays and a direct contact cell proliferation assay. It was found that laser micromachining produces oxides of silicon and platinum on the PDMS and Pt respectively. While the chemical properties of materials were altered, there was negligible change in the biological response to either extracts or cell growth directly on the composite electrode array.

Keywords
Laser micromachining; Microelectrodes; Cytotoxicity; High-density array; Neuroprostheses
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Cytotoxicity of implantable microelectrode arrays produced by laser micromachining
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 5, February 2010, Pages 886–893
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us