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Long-term in vitro degradation of PDLLA/Bioglass® bone scaffolds in acellular simulated body fluid

Paper ID Volume ID Publish Year Pages File Format Full-Text
992 70 2011 12 PDF Available
Title
Long-term in vitro degradation of PDLLA/Bioglass® bone scaffolds in acellular simulated body fluid
Abstract

The long-term (600 days) in vitro degradation of highly porous poly(d,l-lactide) (PDLLA)/Bioglass®-filled composite foams developed for bone tissue engineering scaffolds has been investigated in simulated body fluid (SBF). Foams of ∼93% porosity were produced by thermally induced phase separation (TIPS). The degradation profile for foams of neat PDLLA and the influence of Bioglass® addition were comprehensively assessed in terms of changes in dimensional stability, pore morphology, weight loss, molecular weight and mechanical properties (dry and wet states). It is shown that the degradation process proceeded in several stages: (a) a quasi-stable stage, where water absorption and plasticization occurred together with weight loss due to Bioglass® particle loss and dissolution, resulting in decreased wet mechanical properties; (b) a stage showing a slight increase in the wet mechanical properties and a moderate decrease in dimensions, with the properties remaining moderately constant until the onset of significant weight loss, whilst molecular weight continued to decrease; (c) an end stage of massive weight loss, disruption of the pore structure and the formation of blisters and embrittlement of the scaffold (evident on handling). The findings from this long-term in vitro degradation investigation underpin studies that have been and continue to be performed on highly porous poly(α-hydroxyesters) scaffolds filled with bioactive glasses for bone tissue engineering applications.

Keywords
Bioactive glass; Biodegradable composites; Thermally induced phase separation; Degradation; Poly(hydroxyester)
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Long-term in vitro degradation of PDLLA/Bioglass® bone scaffolds in acellular simulated body fluid
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 2, February 2011, Pages 829–840
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us