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Generation and simulated imaging of pseudo-scaffolds to aid characterisation by X-ray micro CT

Paper ID Volume ID Publish Year Pages File Format Full-Text
9949 654 2009 14 PDF Available
Title
Generation and simulated imaging of pseudo-scaffolds to aid characterisation by X-ray micro CT
Abstract

In order to assess the suitability of polymer tissue scaffolds for use in regenerative medicine, methods to characterise scaffolds are needed. This requires the scaffold's structure to be determined for which X-ray microscopic computed tomography (X-ray micro CT) is widely used. However, because scaffolds are generally made of materials with low X-ray attenuating properties the images produced are far from ideal, which makes distinguishing scaffold material from the pores within it a non-trivial process. This paper presents a method for generating computer-simulated scaffolds that resemble the form of foamed polymer tissue scaffolds. Virtual images of the scaffold are then produced via a simulated X-ray micro CT process enabling the effect of varying the key parameters in the imaging process to be investigated. Here this is assessed via the calculated porosity of the sample, this being a simple measure of a scaffold's properties. Results highlight the difficulties in using X-ray micro CT to characterise scaffolds constructed from materials with low X-ray attenuating properties and suggest strategies that may be adopted in order to improve the quality of the images produced.

Keywords
Modelling; Scaffold characterisation; Micro CT; Image analysis; Porosity; Regenerative medicine
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Generation and simulated imaging of pseudo-scaffolds to aid characterisation by X-ray micro CT
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 25, September 2009, Pages 4233–4246
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us