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The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
9998 657 2007 8 PDF Available
Title
The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles
Abstract

The role of specific and non-specific interactions in the receptor-mediated endocytosis of nanoparticles is analyzed. The characteristic time τwτw, the threshold RthRth and optimal RoptRopt radii for particle endocytosis are estimated as a function of the binding energy factor C, bond elasticity factor G, and non-specific attractive/repulsive factor F at the cell–particle interface. It is shown that the contribution of F is as important as that of C   and GG. General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances.

Keywords
Nanobiotechnology; Bioadhesion; Particle internalization; Surface properties; Drug delivery
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The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 18, 2007, Pages 2915–2922
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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